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3g, h). Ligelizumab binding forces the Cε3 domains right into a extra symmetrical arrangement that closely aligns with the IgE dimer twofold axis outlined because of the Cε4 domains and that's incompatible with FcεRI binding. the flexibility of ligelizumab to bind and dissociate the IgE-Fc3-4:FcεRI complexes indicates that the complicated can dynamically entry conformational states by which the secondary Cε3 area will not sterically block ligelizumab binding.
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